Marqise Lee caught a 75-yard touchdown pass on the first play from scrimmage and returned a kickoff 100 yards for a score, and No. 1 Southern California rolled to a 49-10 victory over Hawaii on Saturday night.
Matt Barkley kicked off his Heisman Trophy campaign with 377 yards passing and four touchdowns, and Lee caught 10 passes for 197 yards for the Trojans (1-0), whose offensive stars were every bit as impressive as expected in their first game since their two-year NCAA bowl ban ended.
Silas Redd rushed for 57 yards and a touchdown on a team-leading nine carries in the Penn State transfer's debut at USC, which led 35-0 at halftime and coasted to its 15th consecutive season-opening victory.
Robert Woods caught six passes for 42 yards and two TDs, and tight end Xavier Grimble caught Barkley's final scoring throw in the fourth quarter.
Hayes Pullard returned an interception 27 yards for a first-quarter score for USC, which outgained Hawaii 481-264.
Duke transfer Sean Schroeder passed for 208 yards and a score in his first start for Hawaii (0-1), which realized it had a rough assignment for coach Norm Chow's debut.
The former USC offensive coordinator is a head coach for the first time after 40 years in the profession, but his Warriors couldn't keep up in the opener of their first season since moving to the Mountain West after 33 years in the WAC.
Schroeder hit Scott Harding with an 18-yard TD pass on the first series after halftime -- but Lee replied with his TD kickoff return. Jeremiah Ostrowski had seven catches for 34 yards for the Warriors.
After going 10-2 and finishing t No. 6 in the final poll last season, the Trojans looked sharp while playing with their first No. 1 ranking since 2008. USC has never lost in eight meetings with Hawaii in a series dating to 1930 and including the 1936 Poi Bowl.
USC was on target from the first snap of Barkley's senior year. After a game-opening touchback, Barkley found Lee with a 5-yard cross-field pass -- and Lee reversed direction and sprinted down the USC sideline for a score.