HONOLULU - Sen. Mazie Hirono (D-HI) made it official on Wednesday morning, with her husband and supporters at her side, she filed the paperwork for re-election. 

Hirono is still fighting advance stage kidney cancer.

"Nothing about this treatment prevents me from doing my job," said Hirono.  

Hirono has been an outspoken critic of President Donald Trump, and pledged to resist the administration. 

"Every single day there's a new thing that makes my head explode," said Hirono, as her supporters laughed.  

Some issues of concern for Hirono include immigration and Deferred Action for Childhood Arrivals (DACA). 

"Sen. Hirono stands for family unity and civil rights," said Maile Hirota, an immigration attorney.  

Hirono could also find herself standing up to an administration that some believe. rejects science. 

"She's always been a champion of the environment," said Jonathan Scheuer, of the Sierra Club.  

Hirono also plans to continue her role as an advocate for women, making sure they have the right to choose. 

"Sen. Hirono has been a long standing champion for women as we continue to fight for right to control our lives and our bodies," said Valerie Lam, of Planned Parenthood.     

If elected, this will mark Senator Hirono's second term in the US Senate.