Lead prosecutor Joseph McGettigan followed Amendola, rebuffing the defense's account of a coordinated action among Sandusky's accusers allegedly bent on financial windfall.
"The great thing about conspiracy theories is you just let them go on and on, until they collapse under their own weight," he said.
McGettigan described the former coach as a pedophile who systematically preyed on his victims using a charity he founded for troubled children, identifying and repeatedly abusing young boys in his care.
"The commonwealth has overwhelming evidence against Mr. Sandusky," he said.
Earlier Thursday, Judge John Cleland announced that three of the counts were dropped against the former coach, bringing the total number of charges to 48.
He told jurors that all three counts pertain to "alleged victim 4," while the defense further petitioned to have all counts related to "alleged victim 8" dismissed as well.
Cleland said one count of involuntary deviate sexual intercourse duplicated another charge. Two other counts -- one of involuntary deviate sexual intercourse and another of aggravated indecent assault -- were not supported by testimony and the evidence presented, Cleland found.
Prosecutors dropped one of the original 52 counts earlier this week because the statute on which that charge was based wasn't in effect on the date of the alleged incident. His accuser said it occurred in 1995 or 1996, but the unlawful contact with a minor statute didn't apply until 1997.
The prosecution had called its only rebuttal witness Tuesday, to counter testimony that raised questions about Sandusky's mental health.
Dr. Elliot Atkins testified that he diagnosed Sandusky with histrionic personality disorder, part of a class of conditions called dramatic personality disorders that are marked by unstable emotions and distorted self-images. But a second psychologist, prosecution witness Dr. John O'Brien, disputed those findings, saying that the "personality profile Mr. Sandusky exhibited was within normal limits."