Around the same time and about 30 miles east in Warren County, heavy snow and low visibility contributed to a crash on Interstate 75 that involved 52 cars, said Ohio State Highway Patrol Sgt. Sean Whickman.
Ten people were sent to hospitals with non-life-threatening injuries and part of the highway was closed for four hours, he added.
Another whiteout near Columbus caused a 23-vehicle crash on Interstate 270 in Westerville, said Lt. Jeff McIntyre of the city's fire department. Four people went to hospitals with minor injuries, he said.
The highway was shut down for more than two hours.
Several people about 55 miles north in Mansfield suffered minor injuries in an accident on Interstate 71 that involved 21 cars and four semis, according to a state highway patrol dispatcher.
All four of these crash sites are among the hundreds of communities under wind chill advisories.
At 30 below zero, frostbite can occur in as little as 10 minutes with the slightest winds, and in five minutes in a brisk breeze, the Centers for Disease Control and Prevention warns.
Newborns, the elderly and the homeless can quickly fall victim to hypothermia.
"Cold weather puts an extra strain on the heart," the CDC said, also noting that overexertion can become even more dangerous to those with heart conditions in the Arctic cold.
Although such deep freezes are potentially deadly, they are not uncommon in the upper midsection of the United States.