There's no shortage of blue blood in the Midwest Region.
The top three seeds -- Louisville, Duke and Michigan State -- are as impressive a trio as could be squeezed into one region.
Louisville, the No. 1 overall seed, reached the Final Four last year. Coach Rick Pitino has been to the Final Four twice as Louisville's coach, and the Cardinals have been to the Elite Eight three of the past five years.
Duke coach Mike Krzyzewski won NCAA titles in 1991, 1992, 2001 and 2010. After an early tournament exit last season, the Blue Devils are back as the No. 2 seed. Duke is an intriguing team now that forward Ryan Kelly is back from a foot injury.
Michigan State, the No. 3 seed, has been a fixture in the Final Four under coach Tom Izzo. The Spartans hung tough in the challenging Big Ten Conference and were in the Top 10 for much of the season.
TEAMS TO BEAT
Louisville (29-5) -- Louisville is the No. 1 overall seed and winner of 10 consecutive games. The Cardinals defeated tournament qualifiers Villanova, Notre Dame and Syracuse on consecutive days, all by double digits, to win the Big East tournament title. If the Cardinals win their first two games, they will play the regional semifinals and finals in nearby Indianapolis.
Michigan State (25-8) -- The Spartans are battle-tested, coming out of a conference that placed seven teams in the tournament. Coach Tom Izzo has reached the Final Four six times in the past 14 years. The last time he reached the Final Four was 2010 in Indianapolis. Michigan State defeated Louisville in the Elite Eight in 2009 in Indianapolis on its way to a national runner-up finish.
No. 12 Oregon vs. No. 5 Oklahoma State: Oregon went 26-8 and won the Pac-12 tournament. The Ducks feature seven players who average between 8.5 and 11.6 points per game. E.J. Singler, whose brother, Kyle, won a national title for Duke in 2010, leads the team with 11.6 points per game.